IFR31 Institut Louis Bugnard
BP 84225
UMR 5241 CNRS UPS
31432 Toulouse Cedex 4
FRANCE

Mission:

We focus our investigations on the different cell subsets contained in stroma fraction of adipose tissues, their respective roles in the biology and plasticity of adipose tissue and their putative uses in regenerative medicine (cardiovascular and blood disease).

Director:

Louis Casteilla, PhD

Background of Director:

PROFESSIONAL EXPERIENCE 1985-1992:
Centre d’endocrinologie CNRS, Meudon, France Permanent scientist INRA 1992-1995
Université Paul Sabatier, Toulouse, France 2nd class Prof. molecular and cell physiology, Head team 1995-2000
Centre National de la Recherche Scientifique Dept 5018, Toulouse, France Vice Director Dept Head Head team 2000
Centre National de la Recherche Scientifique Dept 5018, Toulouse, France 1st class Professor molecular en cell physiology 2000-2005
Centre National de la Recherche Scientifique Dept 5018, Toulouse, France Vice Director Dept Head Head team 2005
Rangos Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Visiting Professor 2007
Centre National de la Recherche Scientifique Dept 5018, Toulouse, France Head of Dept “Plasticity, mitochondria and metabolism”

HONORS: Award of Fondation pour la Recherche Médicale, Cell Biology 1992 SERVICE Scientific advisor board UFR Sciences de la vie et de la terre, Université Toulouse III, France Scientific advisor board Ecole doctorale Biologie, Université Toulouse III Scientific advisor board Groupe Développement Administration committee, Scientific advisor board Association Française d’Etudes et Recherche sur l’Obésité Scientific board of IFATS (International Fat Applied Technology Society)

REVIEWING ACTIVITY: Diabetes, Stem cells, Febs Lett, J. Biol. Chem., Eur heart Journal, Tissue engineering

Major Accomplishments:
We were the first to report:

• the strong angiogenic potential of adipose derived stroma cells
• the spontaneous differentiation towards functional cardiomyocytes of an ASC subset
• the immunosuppresive properties of ASCs

Current Projects:

• Identification of stem cells from adipose tissue able to give rise cardiomycocytes
• Improvement of angiogenic properties of ADScs
• Investigation on adipose tissue homeostasis