Available NIH and FDA approved clinical trial at five centers nationwide for patients who have had a first heart attack within the past 24 hours

What? Phase II clinical trial evaluating the effects of Autologous Bone Marrow Transplantation after Myocardial Infarction (TIME)

Where? Participants receive care at these locations:

• Cleveland Clinic, Cleveland, Ohio
• Minneapolis Heart Institute, Minneapolis, Minnesota
• Texas Heart Institute, Houston, Texas
• University of Florida, Gainesville, Florida
• Vanderbilt University, Nashville Tennessee

Why? To evaluate safety and effectiveness of using a patient’s own stem cells (autologous) to stimulate new heart muscle and blood vessel growth in their heart.

How? Under anesthesia, a bone marrow sample is taken from the patient’s hip bone. Adult stem cells, which have been selected from the bone marrow, are injected into the patient’s heart using a special tube that is placed in one of the vessels going to the heart.  The patient will be followed to assess how their heart responds.

When? This 6-month study is currently accepting patients.  Patients are required be in one of the cities listed above for the procedure and for follow-up evaluation over the next 6 months. 

Who may participate? Patients must meet the following criteria:

• Must be at least 21 years of age
• Must have a first heart attack with a stent placed within 24 hours of symptoms at one of the five institutions above
• Must be stable
• Must have depressed heart function

Who may not participate? Patients may not participate if they meet the following criteria:

• Dangerous heart rhythm
• History of anemia, liver disease, or other chronic disease
• Previous coronary artery bypass
• Unable to provide informed consent
• Women of child bearing potential not willing to practice an active form of birth control

For more information:

Dr. Lemuel A. Moyé
University of Texas School of Public Health
RAS Building
1200 Herman Pressler
Houston, Texas, 77030
E-mail:  This e-mail address is being protected from spambots. You need JavaScript enabled to view it